How to Get and Use the Depleted Mana Rune in PoE 2 Patch 0.5.5

In Path of Exile 2 patch 0.5.5, the Forbidden Rites Event League introduces a challenging hidden questline centered around the Depleted Mana Rune. This rare quest item is tied to Runeseeker’s Pursuit, an endgame progression path that requires both dedicated farming and an unusual mana-stacking challenge.

Unlike ordinary loot, the Depleted Mana Rune is non-tradeable and character-bound, making it an item that each character must obtain independently. Here is everything you need to know about acquiring the rune, reaching the 10,000 Mana requirement, and claiming its unique reward.

How to Get the Depleted Mana Rune

The Depleted Mana Rune has an extremely specific drop source: Uhtred, the Stardrinker, a pinnacle boss encountered through Expedition Grand Logbooks in Secluded Temple maps. The drop rate is reportedly only around 2% to 3%, so players should expect to run the encounter multiple times before obtaining the quest item.

For more efficient farming, players can use Uhtred’s Saga, which typically costs around 1 Divine Orb on the market. Keeping Uhtred’s Saga active in your inventory guarantees an Uhtred encounter when you next open an Ocean biome Logbook. This makes the process considerably more predictable than relying on random encounters.

Important Character-Bound Restriction

The Depleted Mana Rune is a quest item, so it cannot be traded between players. You need to personally defeat Uhtred and receive the drop. The rune can also only be obtained once per character, meaning players cannot repeatedly farm the item on the same character.

The 10,000 Mana Challenge

Obtaining the Depleted Mana Rune is only the beginning. The real challenge comes when you attempt to activate it. Simply right-clicking the rune will not work. Instead, your character needs to reach a massive 10,000 maximum Mana threshold. This requirement makes temporary character customization an important part of the quest.

Step 1: Reach 10,000 Maximum Mana

You need to modify your equipment and passive-tree setup until your character has at least 10,000 maximum Mana. One approach is to temporarily respec into a heavily mana-focused build. Players can also make use of Undying jewel setups combined with Map Remnants to push their Mana pool significantly higher during a map. Because this setup is primarily designed to satisfy the quest requirement, it may not be practical as a permanent build.

Step 2: Infuse the Rune

Once your maximum Mana reaches 10,000 or more, right-click the Depleted Mana Rune. The rune will consume your Mana and transform into an Infused Mana Rune. This transformation is the key step needed to complete the quest progression.

Runeseeker’s Call: The Quest Reward

After obtaining the Infused Mana Rune, take it to Farrow in your hideout. Farrow rewards you with Runeseeker’s Call, a unique Runic Fork weapon designed around Rune-based spellcasting.

Its notable properties include:

· 5 fixed sockets

· 200% increased effect of socketed Runes

· A unique setup aimed at high-end Rune spellcasters

The combination of fixed sockets and the increased effect of socketed Runes gives the weapon considerable value for characters that can take advantage of its mechanics.

Is the Quest Worth Farming in Patch 0.5.5?

The economics of the quest are an important consideration. Getting the Depleted Mana Rune requires repeated Uhtred encounters, while temporarily restructuring a character to reach 10,000 Mana can also require an investment in gear and passive-tree changes.

However, Runeseeker’s Call can command a substantial market premium, particularly in an uncorrupted state. This creates an incentive for players to complete the quest specifically to sell the resulting weapon.

For players managing their PoE 2 currency, the main calculation is whether the cost of Uhtred’s Saga, additional Logbook runs, and temporary Mana-focused gear is justified by the potential value of the reward.

The process also illustrates an important distinction between ordinary PoE 2 items and quest-specific rewards: although the Depleted Mana Rune itself cannot be traded, the resulting unique weapon can become a valuable market asset.

A Practical Farming Route

For players targeting Runeseeker’s Call, the overall process can be summarized as follows:

1. Obtain an Expedition Grand Logbook containing the relevant Ocean biome.

2. Purchase Uhtred’s Saga if you want to guarantee the Uhtred encounter.

3. Open the Logbook and defeat Uhtred, the Stardrinker.

4. Repeat the encounter until the Depleted Mana Rune drops.

5. Temporarily adjust your build to reach 10,000 maximum Mana.

6. Right-click the Depleted Mana Rune to create the Infused Mana Rune.

7. Take the infused rune to Farrow in your hideout.

8. Claim Runeseeker’s Call.

9. If you are farming for profit, evaluate the current market value before deciding whether to keep or sell the uncorrupted weapon.

The biggest obstacles are the low rune drop rate and the unusual 10,000 Mana requirement. Preparing your farming resources in advance can reduce the amount of time spent switching between builds and Expedition encounters.

What Makes the Depleted Mana Rune Unique?

The Depleted Mana Rune stands out because it combines several unusual mechanics into a single progression path. It is exceptionally rare, cannot be traded, has a strict per-character acquisition limit, and cannot simply be activated through normal item interaction.

Its 10,000 Mana requirement effectively turns the quest into a temporary buildcrafting puzzle. Rather than testing only combat strength, the quest asks players to manipulate their character’s maximum-resource mechanics before they can unlock the final reward.

For dedicated Expedition farmers and Rune-focused spellcasters, that combination makes Runeseeker’s Pursuit one of the more distinctive pieces of endgame content in Path of Exile 2 patch 0.5.5.

The U4GM Team