If you're looking to enhance your build in Path of Exile 2, understanding how to acquire and use Inspiration Runes is essential. Whether you're a new adventurer or a seasoned warrior, these runes offer powerful cold-based bonuses across weapons and armor. In this guide, we’ll break down the effects and recipes for the Lesser, Standard, and Greater Inspiration Runes to help you optimize your gear. For those who want to speed up progression, you can also buy PoE 2 Currency to get the resources you need faster and more efficiently.

| Rune Type | Martial Weapons Effect | Armour Effect | Wand or Staff Effect |
|---|---|---|---|
| Lesser Inspiration Rune | Adds 3 to 5 Cold Damage | +10% to Cold Resistance | Gain 8% of Damage as Extra Cold Damage |
| Inspiration Rune | Adds 6 to 10 Cold Damage | +12% to Cold Resistance | Gain 10% of Damage as Extra Cold Damage |
| Greater Inspiration Rune | Adds 9 to 15 Cold Damage | +14% to Cold Resistance | Gain 12% of Damage as Extra Cold Damage |
Place into an empty Rune Socket in a Weapon or Armour to apply its effect to that item. Once socketed it cannot be removed.
Inspiration Rune can drop anywhere.
Lesser Inspiration Rune or Inspiration Rune is used in the following recipes:
| Rune Type | Drop Level | Recipe |
|---|---|---|
| Lesser Inspiration Rune | 16 | N/A |
| Inspiration Rune | 41 | 3x Lesser Inspiration Rune |
| Greater Inspiration Rune | 59 | 3x Inspiration Rune |