How to Get Runeseeker’s Call in PoE 2

Runeseeker’s Call is one of the more interesting Unique Wands available in Path of Exile 2’s endgame. Unlike many Uniques that only drop from bosses, this weapon is primarily obtained through a special Expedition questline, making it a guaranteed reward for players who complete the required objectives.

From our experience, Runeseeker’s Call is especially valuable for builds that heavily utilize Runes and Mana scaling. Its unique interaction with Rune bonuses creates opportunities that few other POE 2 Items can match, making it well worth pursuing if your build can take advantage of its mechanics.

What Is Runeseeker’s Call

Runeseeker’s Call is a Unique Wand obtained through an Expedition-related endgame quest or by purchasing it from other players through the trade market.

Its defining feature is an inherent five Augment Sockets, accompanied by a powerful modifier that increases the effectiveness of every Rune socketed into the weapon by 200%.

Even more importantly, this bonus also affects Bonded modifiers unlocked through the Shaman’s Wisdom of the Maji system, allowing players to dramatically increase the value of certain Rune combinations.

How to Get Runeseeker’s Call

There are two primary methods for acquiring this Unique Wand.

Complete the Expedition Questline

The intended method is progressing through the Expedition endgame questline.

Although the process is straightforward overall, it includes several important steps and a small amount of randomness.

Trade With Other Players

Players who don’t want to complete the quest themselves can purchase Runeseeker’s Call through the player economy.

Depending on league progression and demand, acquiring enough POE 2 Currency for the trade may sometimes be faster than farming every quest requirement yourself.

Step 1: Obtain the Depleted Mana Rune

Your journey begins with the Expedition pinnacle boss, Uhtred, the Stardrinker.

Among the boss’s possible rewards is a rare quest item called the Depleted Mana Rune.

This item does not drop every time, so players should expect to defeat Uhtred multiple times before obtaining it. Fortunately, these runs also provide opportunities to collect valuable POE 2 Items and additional crafting resources along the way.

Step 2: Speak With Farrow

After obtaining the Depleted Mana Rune, return to Farrow.

Handing over the quest item unlocks new dialogue that explains the next stage of the quest and provides clues about how to activate the mysterious Rune.

Although the conversation is brief, it serves as the gateway to the most challenging part of the entire questline.

Step 3: Charge the Depleted Mana Rune

To transform the Depleted Mana Rune, you’ll need to accumulate at least 10,000 total Mana.

This requirement includes Overflowed Mana, meaning mechanics such as Sacrifice of Mind and Mana Remnants can help you reach the necessary threshold.

For many characters, achieving 10,000 Mana requires temporary adjustments to both gear and passive skills.

We recommend focusing on:

· Maximum Mana modifiers

· Mana-increasing passive nodes

· Equipment that boosts Mana scaling

· Temporary gear swaps if necessary

Once your total Mana reaches the required amount, simply right-click the Depleted Mana Rune to convert it into an Infused Mana Rune.

Step 4: Exchange for Runeseeker’s Call

The final step is the easiest.

Return to Farrow once more with the Infused Mana Rune.

Additional dialogue options will appear, allowing you to exchange the completed quest item for Runeseeker’s Call.

Once obtained, the wand becomes available immediately for your build.

Why Runeseeker’s Call Is Valuable

The true strength of Runeseeker’s Call lies in its Rune synergy.

Its five Augment Sockets provide exceptional flexibility, while the 200% increased Rune effectiveness dramatically amplifies the power of socketed bonuses.

Because the modifier also affects Bonded bonuses unlocked through Wisdom of the Maji, players can create highly specialized builds that gain significantly more value from Rune investment than they could with conventional weapons.

For Rune-focused characters, this makes Runeseeker’s Call one of the most distinctive POE 2 Items currently available.

Tips Before Starting the Quest

Preparing ahead of time makes the quest considerably easier.

If your character naturally has low Mana, consider temporarily equipping Mana-focused gear before attempting the charging step.

Saving useful Mana equipment throughout your progression can eliminate the need to purchase expensive replacements later.

Players who prefer trading should also monitor market prices. Depending on the economy, spending POE 2 Currency to purchase Runeseeker’s Call may be more efficient than repeatedly farming Uhtred for the initial quest item.

Is It Worth Farming

For builds that rely on Rune interactions, absolutely.

While the quest requires patience—especially if the Depleted Mana Rune refuses to drop—the reward offers unique mechanics that cannot easily be replicated elsewhere.

Even if your current character doesn’t need the wand, it may remain a valuable trade asset due to continued demand from Rune-focused builds throughout the league.

Runeseeker’s Call is one of the most rewarding Unique quest items in Path of Exile 2’s Expedition endgame. Although acquiring it requires defeating Uhtred, completing a Mana-based quest objective, and investing some preparation, the resulting weapon offers exceptional Rune synergy and long-term build potential.

Whether you choose to complete the quest yourself or acquire it using POE 2 Currency, Runeseeker’s Call remains one of the more unique POE 2 Items for players exploring advanced Rune mechanics.

The U4GM Team