In Path of Exile 2, smart use of Orbs of Chance can lead to powerful and highly valuable unique items—if you know what to target. Whether you're chasing rare gear or optimizing your build, understanding which base items offer the best returns is key. The table below highlights some of the top choices for chancing, along with their unique outcomes and what to keep in mind before you roll. And if you need a boost, don’t forget you can always buy PoE 2 Currency to speed up your journey.

| Base Item | Potential Unique(s) | Value Tier | Notes |
|---|---|---|---|
| Stellar Amulet | Astramentis | Insane Value | Extremely rare; high risk with significant reward. |
| Sapphire Ring | Dream Fragments | Insane Value | Slightly more common than Astramentis; still a high-risk gamble. |
| Heavy Belt | Headhunter | Very High Value | Classic chase unique; rarity is high but attainable. |
| Emerald Ring | Thief's Torment, Death Rush | Moderate to High | Both outcomes have value; higher chance of success compared to top-tier items. |
| Gold Ring | Ventor's Gamble, Andvarius | Variable | Ventor's Gamble's value depends on roll; Andvarius offers consistent moderate value. |
| Ornate Belt | Ryslatha's Coil | Moderate to High | Value depends on roll; more common than top-tier uniques. |
| Solar Amulet | Fireflower | Variable | Potentially high value when corrupted; base item also useful for crafting. |
| Moulded Mitts | Atziri's Acuity | Moderate | Value depends on current meta; ensure base item is correct. |
| Gold Amulet | Eye of Chayula, Serpent's Egg | Low to Moderate | Niche uses; value can fluctuate based on build popularity. |
| Attuned Wand (iLvl ≤5) | Lifesprig | Moderate | Valuable for leveling; ensure item level is 5 or below for optimal use. |
Key Considerations:
Using Orbs of Chance is inherently risky, but with informed choices, you can maximize your chances of obtaining valuable uniques.