In Path of Exile 2, GGG introduces a range of powerful socketable items known as Talismans—each bringing unique effects that enhance build creativity and depth. Among them is the Talisman of Thruldana, one of the seven newly revealed Talismans. These mystical artifacts are rare drops from Azmerian Spirit-possessed enemies, adding not just power, but an element of thrill to monster hunts.

Primary Effects:
This talisman modifies poison mechanics by allowing an additional stack of your poison to affect enemies simultaneously. While it reduces the duration of poison effects by 25%, the stacking advantage can dramatically improve your damage-per-second output—particularly in rapid-hit, DoT-focused builds.
"Place into an empty Rune Socket in a Weapon or Armour to apply its effect to that item. Once socketed it cannot be retrieved but can be replaced by other socketable items."
This means strategic planning is essential. Once you commit a Talisman to a piece of gear, it becomes a permanent enhancement (until overwritten). Be sure the item you socket this into aligns with your long-term poison-focused build strategy.
The Talisman of Thruldana is a deceptively powerful tool for poison-centric players. Its ability to stack an additional poison instance can significantly alter how damage over time scales in combat. Although it shortens poison duration, the trade-off may result in higher total damage if leveraged with fast attacks and high application frequency.