In Diablo 4, Mythic Unique Greater Affixes are extremely rare and powerful enhancements that significantly boost the effectiveness of certain Unique items. These affixes provide massive increases to offensive capabilities, resource efficiency, and utility, making them essential for conquering high-level challenges and endgame content. Whether you're optimizing damage output or improving survivability, these affixes can transform your build. Explore the full list below, categorized by Offensive, Resource, and Utility roles—and don’t forget, you can buy Diablo 4 Items to upgrade your gear faster and gain a competitive edge.
| Name | Description | Classes | Item Types |
|---|---|---|---|
| 1HSword Unique Generic 001 | Lucky Hit: Up to a 25% chance to deal 900 Shadow damage to surrounding enemies and reduce their damage dealt by 20% for 5 seconds. | Barbarian, Druid, Necromancer, Rogue, Sorcerer | 1H Sword |
| 2HSword Unique Generic 001 | Increases your Critical Strike Damage by 100%[x]. The other properties on this weapon can roll higher than normal. | All | 2H Sword |
| 2HStaff Unique Generic 100 | Gain a random Shrine effect for 20 seconds after killing an Elite enemy. Can only occur once every 30 seconds. | Barbarian, Druid, Necromancer, Rogue, Sorcerer | 2H Staff |
| Helm Unique Generic 004 | Succumb to hatred and earn Mother's Favor, increasing your damage dealt by 60%[x]. Slaughter enemies to briefly steal Mother's Favor from Nearby allies. | All | Helm |
| 2HPolearm Unique Generic 001 | Enemies afflicted by more Damage over Time than remaining Life are Executed. | All | 2H Polearm |
| Helm Unique Generic 001 | Lucky Hit: Up to a 20% chance to trigger a poison nova that applies 6,000 Poisoning damage over 5 seconds to enemies in the area. | All | Helm |
| Chest Unique Generic 127 | While at full Life, your Skills unleash a divine barrage dealing 195 damage. | All | Chest |
| Name | Description | Classes | Item Types |
|---|---|---|---|
| Ring Unique Generic 101 | Spending your Primary Resource reduces the Resource cost of your Skills and increases your damage by 10%[x] for 3 seconds, up to 50%[x]. | All | Ring |
| Name | Description | Classes | Item Types |
|---|---|---|---|
| Helm Unique Generic 002 | Gain 20% Damage Reduction. In addition, gain +4 Ranks to all Skills. | All | Helm |
| Amulet Unique Generic 100 | Gain 60 Maximum Resource. When taking damage, 75% is drained as 2 Resource for every 1% of Maximum Life you would have lost. | All | Amulet |
Mythic Unique Greater Affixes add an intense layer of depth to character builds in Diablo 4. Whether you're stacking critical damage, maximizing your uptime with shrine buffs, or enhancing your survivability through resource management, these affixes offer the elite edge for dominating Sanctuary. Players should keep an eye out for these affixes when building high-end loadouts and pushing through the most challenging content in the game.